Chronic lymphocytic leukemia (CLL) remains the most common leukemia of adults and is incurable. Several novel therapies have substantially altered the treatment landscape for CLL, and studying the mechanisms of their activity, toxicity and resistance is of great interest. Our lab focuses on CLL, somatic and germline genomics of CLL and the mechanisms of these targeted therapies in CLL. CLL is one of the most familial of all cancers but the genetic basis of this remains poorly defined. We have previously shown that rare variants in ATM are associated with CLL, and this position will focus both on biological validation of the effects of those variants, as well as new gene discovery focused on the genomic study of familial CLL. We have a huge tissue bank of over 2500 CLL patients and over 1500 familial lymphoma patients that will provide the samples for these investigations.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
This familial CLL fellowship will involve in vitro validation of the functional effects of ATM variants in primary cells and cell lines as well as extensive genomic analysis of primary CLL samples. The ideal candidate will be able to perform their own bioinformatics analyses of genomic data. Validation of key findings at the bench will also be required. The ideal candidate will have familiarity and experience working with molecular genetics/genomics, molecular biology, flow cytometry, cell culture and bioinformatics.
Previous experience in molecular biology, cell biology, flow cytometry and informatics is required. These positions will both include high-throughput genomic analyses and require good computational skills and familiarity with bioinformatics. MD, PhD or MD/PhD is required.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.