Chemical Biologist (Scientist) - Center for Protein Degradation

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450 Brookline Ave, Boston, MA 02215

Research Laboratory

Employment Type:
Full time

Work Location:
Onsite:Up to 1 day remote/wk


The Center for Protein Degradation (CPD) seeks a highly motivated individual to join the team as a SCIENTIST who will work on various projects focused on the development of therapeutic degraders and molecular glues. Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered into a collaboration to create the Center for Protein Degradation (CPD) at DFCI. The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into novel therapeutic approaches. This individual will be an important member of our research team and will be centrally involved in assisting various research projects using their expertise in chemical biology.


Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

  • Take a leading role in chemical biology at the center. Projects include hit generation, therapeutic target identification and validation, and drug-target engagement studies.
  • Design, synthesize and apply functional small molecule chemical probes to illuminate new therapeutic opportunities
  • Independently plan, manage, and perform experiments and identify next steps based on outcomes. Develop project proposals, timelines, and resource needs.
  • Communicate project progress to the group, and to leadership.
  • Interact and liaise with internal experts, external experts, academic groups, and CROs to establish and direct collaborations and projects.
  • Prepare papers and publications, as appropriate.


  • PhD degree in chemical biology or a related discipline.
  • Strong background in synthetic organic chemistry, to enable functional probe design and synthesis
  • Experience in chemoproteomics is preferred.
  • Familiarity with chemical biology techniques used to assess interactions between proteins and small molecules.
  • Excellent communication and presentation skills.
  • Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals
  • Ability to work independently as well as in a collaborative team environment
  • Excellent organizational and prioritization skills. Strong attention to detail.
  • Ability to collect and analyze experimental data, prepare research publications and communicate results.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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