Senior Scientist - Director Metabolomics Facility

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450 Brookline Ave, Boston, MA 02215

Research Laboratory

Employment Type:
Full time

Work Location:
Onsite:Up to 1 day remote/wk


Dana-Farber Cancer Institute is seeking an experienced PhD-level Metabolism Scientist to lead the Institute’s new small molecule metabolomics core facility, to develop and apply state of the art approaches and to investigate cellular and organismal metabolism.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


  • Lead the design and execution of experiments to deliver a diverse set of metabolomics data, including targeted and non-targeted steady-state metabolomics as well as stable isotopic labeling data and flux analysis.
  • Provide scientific and technical leadership to promote metabolomics at Dana-Farber and among the Institute’s academic and industry collaborators.
  • Develop the Institute’s metabolomics platform, working in collaboration with the Core’s industrial metabolomics partners to apply in-licensed metabolomics tools, and over time establish novel metabolic capabilities to further enhance discovery research.
  • Use both commercial and proprietary informatics/software tools for analysis of complex data from metabolomics (targeted and untargeted) and flux experiments to evaluate cellular metabolism; interpret results in the context of current literature and established metabolic understanding.
  • Implement best practices for operation and maintenance of core instrumentation.
  • Develop operating budgets using established accounting standards to insure the sustainable financial operation of the facility.
  • Manage the Core’s scientific and technical staff and create a positive, supportive work environment within the Core.
  • Interact proactively with Dana-Farber researchers and collaborators.


  • The candidate should hold a PhD in any area of the chemical, biological, or biochemical engineering sciences plus at least two years of post-doctoral training. Industry research experience (bio/pharma R&D, metabolic engineering, synthetic biology) is a plus.
  • At least 5 years of experience with LCMS-based metabolomics data acquisition, instrument operation, and instrument maintenance.
  • Excellent track record of scientific research showing evidence of both analytical excellence and ability to address biology questions with depth, rigor, and creativity, as in peer-reviewed publications, scientific presentations and patent filings.
  • Informatics skills are a significant plus, including familiarity with Matlab, scripting languages (python, R, shiny), and more generally, aptitude operating within an informatically-driven research environment.
  • LCMS-based lipid profiling expertise is an asset for this role.
  • The ideal candidate will be comfortable working at the interface of chemistry and biology, dealing with quantitative physical measurements, and concepts of metabolic flux analysis and stable isotope labeling studies.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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