Experimental Research Technician, Liu Lab

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Job ID:

450 Brookline Ave, Boston, MA 02215

Research Technician/Scientist

Employment Type:
Full time

Work Location:
Onsite:Up to 1 day remote/wk


The X. Shirley Liu lab seeks a highly motivated individual to join our team as a full-time experimental research technician. Our laboratory is based at Dana-Farber Cancer Institute and affiliated with Department of Statistics at Harvard T.H. Chan School of Public Health. We combine a wide variety of approaches to address cutting-edge problems in multiple research areas, including epigenetic regulation of gene expression, determinants of cancer immunotherapy response, inference of immune receptor - antigen interaction, and novel functional genomic assays.

The Liu Lab has extensive track record in translational cancer research and algorithm development, as demonstrated by our recent papers:

Cancer Immunology: (Li et al, Nat Genet 2016; Liu & Mardis, Cell 2017; Pan et al, Science 2018; Jiang et al, Nat Med 2018; Hu et al, Nat Genet 2019; Cader et al, Nat Med 2020; Gu et al, Cancer Discov 2021)

Cancer Epigenetics: (Xu et al, Science 2012; He et al, Nat Methods 2014; Liu et al, PNAS 2017; Mei et al, Cancer Res 2017; Qin et al, Genome Biol 2020; Chen et al, Nat Commun 2020)

CRISPR screens: (Li et al, Genome Biol 2014; Xu et al, Genome Res 2015; Zhu et al, Nat Biotech 2016; Fei et al, PNAS 2017; Xiao et al, PNAS 2018; Fei et al, PNAS 2019; Wang et al, Nat Protoc 2019)

Algorithm development: (Zhang et al, Genome Biol 2008; Li et al, Genome Biol 2015; Li et al, Nat Genet 2017; Jiang et al, Cell Systems 2018; Song et al, Nat Methods 2021; Tokheim et al, Mol Cell 2021)

Data integration: (Jiang et al, PNAS 2015; Jiang et al, Genome Biol 2015; Zang et al, Nat Comm 2016; Du et al, Nat Comm 2016; Zhang et al, Nat Commun 2020; Zeng et al, Clin Cancer Res 2020)

We believe that the successful operation of the whole lab relies on the realization of personal goals of every member. Therefore, we encourage and assist comprehensive self-improvement, and provide training in both experimental and computational approaches to our members. We also encourage and support our technicians to further pursue their scientific career after their stay with us.

The Liu lab is a vibrant and happy family, where members are very supportive of each other. In addition to the intensive academic work, we organize after-work games/parties/trips to enrich ourselves.


The research technician will be an important member of our team, and will be engaged in various experimental projects applying a variety of techniques including:

  • molecular cloning,

  • CRISPR screen,

  • cancer-immune co-culture,

  • mouse in vivo operations, and

  • single-cell profiling technologies.

Responsibilities will also include some aspects of laboratory management and maintenance.


At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

  • Bachelor’s Degree (by May 2022) required with a major in biology or chemistry preferred.
  • Excellent communication and collaboration skills.
  • Excellent logical skills and learning ability.
  • Pay attention to details and be thorough in completing work tasks.
  • Previous biology/biochemistry lab experience preferred.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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