Postdoctoral Research Fellow-Marasco Lab

Job Details

Job ID:

450 Brookline Ave, Boston, MA 02215


Employment Type:
Full time

Work Location:
Onsite: 4-5 days onsite/week


Our group at Dana-Farber Cancer Institute is looking for an exceptional Postdoctoral Research Fellow to conduct research on COVID in the area humoral cross-reactivity to circulating coronaviruses and pan-coronavirus vaccines.

The project will explore the hypothesis in two parts; 1), that prior immunity against circulating coronaviruses can result in the development of antibodies that cross-bind and neutralize both endemic coronavirus and SARS-CoV-2. Utilizing our large COVID-19 convalescent patient cohort in combination with a cohort collected pre-pandemic, the primary goal of this project is to provide evidence of these cross-reactive antibodies and to establish the molecular basis by which coronavirus cross immunity arises through the identification of common spike epitopes.  2), we have established a humanized mouse model that will allow us to develop mosaic spike based pan-coronavirus vaccines based on the above principles.  We will analyze 10X genomics and LibraSeq to perform in depth analysis of the B cells to understand the molecular basis of immune imprinting and memory.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned innovative researchers, dedicated clinicians and professionals, and allies in the common mission of conquering cancer, HIV/AIDS and related diseases.  Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients; we conduct research that advances treatment; educate tomorrow's researchers/ physician; reach out to underserved members of our community; and work with amazing partners, including other Harvard Medical School-affiliated hospitals.


Our lab at Dana-Farber Cancer Institute is seeking a motivated and talented fellow who will contribute to discovery and translational research.  The major focus of this specific position will be for a very talented  and committed fellow to perform serologic and molecular studies, develop and execute biological assays, interpret the results, analyze the data, and support further research activities.  We are looking to expand our laboratory of creative, collaborative, yet independent thinkers, with high scientific rigor and enthusiasm who are most likely to succeed within our team. Mentorship of the candidate will focus on the development and publication of high-impact research projects and preparing the fellow for a career as an independent academic investigator or for a position in the biomedical industry.

  • Execute serologic studies to quantify cross-reactivity in COVID-19 convalescent and control plasma samples
  • Purify plasma IgGs for in vitro and in vivo characterization and neuralization experiments
  • Conduct cell-based and molecular biology research aimed at isolating immune B cells from the two human cohorts for the discovery of cross-reactive antibodies. 
  • Production and characterization of these mAbs for epitope binning, kinetic binding measurements and neutralization activity
  • Maintaining accurate records, writing reports, and preparing/giving presentations.


  • PhD, MD, MD/PhD or docotoral equivalent with interest in the biological sciences
  • A strong background in immunology, molecular biology and cell biology
  • Excellent oral and written communication skills
  • Ability to perform both self-directed and guided research
  • Effectively work as part of an interdisciplinary team of scientists

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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