Preclinical In Vivo Associate

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Job ID:

450 Brookline Ave, Boston, MA 02215

Research Laboratory

Employment Type:
Full time

Work Location:
Onsite: Full time on Campus


We are seeking a highly motivated individual to join a preclinical in vivo pharmacology associates’ team in a fast-paced and collaborative environment at the Experimental Therapeutics Core Facility at Dana-Farber Cancer Institute. The position reports directly to the Head of Experimental Therapeutics Core. 

The individual will work closely with the preclinical and clinical scientists at the Institute and leading industry collaborators to design and execute oncology-related mouse studies. Individuals will have access to extensive training in mouse handling and in vivo skills necessary for procedures to participate in the preclinical research setting actively. Studies focus on cancer model development and testing a variety of novel cancer therapies by monitoring in vivo disease progression through various modalities- like bioluminescence imaging, flow cytometry, or caliper measurement. Studies run through the Experimental Therapeutics Core lead to further world-class research or high-ranked publications. 

A successful candidate, once trained, requires the ability to organize and manage a workload independently while aiding team members in building a collaborative environment. They would need to keep detailed, accurate records of completed studies to report findings to investigators, resulting in further research or publication. 

The position is at 27 Dry Dock Ave, South Boston

The Preclinical Imaging Associate will perform scientific research, which includes design and execute oncology related mouse studies using bioluminescence (BLI) imaging as well as the entire spectrum of conventional (e.g., caliper measurements, clinical scoring) endpoints to evaluate pre-clinical novel cancer therapies.  They will perform set up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results to meet the requirements of industry sponsored research agreements. They must maintain a professional demeanor in communications with collaborators. They must be able to take necessary initiative to meet project timelines and deliverables. Must be able to understand and follow the Animal Resource Facilities standard operating procedures and institutional guidelines and policies. Individual must understand and follow the local, state, federal and regulations and guidelines for working with in vivo research models.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


  • Responsibilities:

    • Routine handling, restraint, identification (including ear notching and tattooing) of mice or rats
    • Establish and maintain mouse and rat cancer models to test efficacy, tolerability, and PK/PD of novel therapeutics 
    • Independently execute in vivo studies by dosing therapeutics agents by various routes (e.g., oral gavage, intraperitoneal, intravenous)
    • Monitor cancer progression through bioluminescence imaging, flow cytometry, or caliper measurements. 
    • Perform blood draws, necropsies, and process ex vivo samples
    • Perform mammalian cell culture and maintenance of cell lines 
    • Interpret, present, and document experiments based on data generated to investigators, often leading to further experiments or publications.
    • Responsible for maintaining and reporting accurate records of inventory/ equipment
    • Follow IACUC requirements (animal standard operating procedures) and DFCI institutional guidelines and policies.


    • Bachelor’s degree required with a major in biology, Animal Sciences or related Life Sciences preferred.
    • Requires 0-2 years of related experience.
    • Learns and uses technical principles, processes, and concepts.
    • Developing technical expertise, applies Institute policies and procedures to resolve a variety of issues.
    • Works on problems of limited to moderate scope.
    • Follows standard practices and procedures in analyzing situations or data from which answers can be readily obtained.
    • Builds stable working relationships internally.
  • Nice to have: 

    • Experience with animal handling (mouse) and execution of in vivo studies
    • Mammalian cell culture 
    • Experience with small animal imaging modalities and flow cytometry


At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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