Research Associate II - Center for Protein Degradation

Job Details

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Job ID:
20963

Location:
450 Brookline Ave, Boston, MA 02215

Category:
Clinical Research

Employment Type:
Full time

Overview

Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a multi-year collaboration to create the Center for Protein Degradation (CPD) at DFCI led by Drs. Eric Fischer, Nathanael Gray and Lyn Jones. The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions.
 
This individual will be an important member of our research team and will be centrally involved in assisting various research projects primarily involving protein biochemistry. In addition to the bench-based research, responsibilities will also include some aspects of laboratory management and organization. Training is available in all aspects of experimental research.
 
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
 

Requirements

Responsibilities:
  • Responsible for ordering consumables for the CPD and tracking of the received items via internal ordering system, with fellow scientist at the CPD as well as with vendors
  • Management of laboratory supplies and consumables
  • Conduct standard biological or biochemical assays and laboratory analyses, e.g., TR-FRET, FP, AlphaScreen, and cell-based assays, etc.
  • Purify and prepare proteins for the in-vitro
  • Generate and validate lentiviral stable lines
  • Maintain and perform drug treatments on cell cultures
  • Compile and analyze experimental data. Develop a summary of findings for presentation to Center personnel.
  • Use computers, computer-interfaced equipment, robotics and/or high-technology applications to perform work duties
  • Set up, calibrate and operate lab equipment
  • Prepare and maintain laboratory reagents and stocks
  • Maintain work areas and order supplies, as needed
  • Keep up to date with appropriate literature and research publications related to work and projects
  • May be responsible for designing and executing advanced experiments
  • Maintain clear and accurate records of experimental work (e.g., experiment methods, results/findings) in a lab notebook
  • Monitor laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.

Qualifications

Qualifications:
 
  • Bachelor's Degree required; major in biology or chemistry preferred
  • Knowledge of techniques related to biology, chemistry or medicine, with 1-3 years of professional experience
  • Excellent communication skills (written and verbal)
  • Ability to document and analyze information/data and use logic to address work-related issues and problems
  • Organized, with close attention to detail and strong time management skills.
  • Thorough in completing work tasks
  • Ability to work within a team environment
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