The Reinherz lab at Dana-Farber Cancer Institute and Harvard Medical School is recruiting a postdoctoral fellow to study HIV-1 vaccine immunology. We use interdisciplinary approaches at the interface of structural, molecular mechanism of antibody-mediated protection and vaccine immunology with the aim of translating these insights into HIV-1 vaccine development. Specific research directions include molecular mechanism of broadly neutralizing antibody, B cell humoral immunity of vaccines and strategies to modulate B cell affinity maturation. The laboratory provides a rich training environment and access to cutting-edge techniques.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities: The postdoctoral fellow will work on HIV -1 env vaccine development and modulation of B cell affinity maturation. Cloning, expression and purification of proteins, cell culture, mouse model immunization studies, immune sera analyses, FACS for immune cells analyses, B cell repertoire analysis are key tasks.
Highly-motivated candidates with a recent PhD or MD/PhD in biomedical sciences and significant experience in molecular biology, biochemistry and immunology are encouraged to apply. Skills in molecular cloning, biochemistry and cell culturing techniques/protein expression are essential. Technical experience in immunology and methods to examine immune responses (measurement of antibodies, B and T cell responses and B cell repertoire analyses and mouse modeling/handling etc.) are highly desirable. Candidates should have a publication record in peer-reviewed journals. We are seeking a candidate with excellent writing and communication skills, able to work independently but also effectively with other lab members. Applicants should include a short statement of research goals, CV and three references with their application.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.