Research Fellow- GU Oncology

Job Details

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Job ID:
23834

Location:
450 Brookline Ave, Boston, MA 02215

Category:
Fellowships

Employment Type:
Full time

Overview

The Gelb Laboratory at Dana-Farber Cancer Institute and Harvard Medical School studies Genitourinary Oncologic (GU) cancers, particularly prostate, kidney and other genitourinary cancers. We utilize variety of molecular biology and genomic approaches to understand GU cancer with major focus areas including: 1) Defining and validating the essential factors in GU cancers involved in response to immunotherapy; 2) Understanding the genetic and phenotypic changes that drive cancer progression through genomic and transcriptomic analysis of tumor biopsies; 3) Functional studies on mechanisms involved in resistance to targeted drug therapies.  Research in the laboratory ranges from basic mechanistic investigation of cancer gene function to highly translational genomic and functional studies of patient-derived tissues from clinical trials. Team members work in a highly collaborative environment that includes laboratory investigators, clinical investigators and computational biologists at Dana-Farber Cancer Institute. We are seeking enthusiastic, dedicated and hardworking post-doctoral scientists to join our team. The successful candidate will have a strong interest in cancer biology and therapeutics with experience in molecular biology, cell biology, genetics/genomics or biochemistry.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Requirements

A post-doc. position is available in the Gelb Center for Translational Research under the supervision of Dr. Toni Choueiri. The Gelb Center leverages our biobank of patient samples to answer important questions focused on different aspects of kidney, bladder, and prostate cancers. We are specifically interested in molecular genetic programs that are involved in cancer progression and cancer response to specific targeted therapies or immunotherapy. Frequently used techniques include mammalian cell culture, transcriptomics, and functional assays.

Specific responsibilities may include:

  • Performing cell and molecular biology research including but not limited to cell culture, genetic manipulation through shRNA/CRISPR, protein/RNA/DNA analyses including Western blotting, RNA-seq, IP-MS, and ChIP-seq.
  • Lentiviral transduction techniques for ORF-overexpression experiments or RNAi and CRISPR-Cas9 knockdown/knockout experiments.
  • Performing a variety of basic cancer biology assays, including in vitro proliferation or apoptosis assays, drug sensitivity assays, soft agar assays and in vivo xenograft experiments.
  • Cell biology studies to examine the consequences of therapeutic targeting of cancer cells in in vitro and in vivo models.
  • Working with a team of experimental and computational biologists to effectively interpret whole exome sequencing and RNA-sequencing data as well as gain- and loss-of-function genetic or pharmacologic screening data.
  • Performing detailed characterization and cellular mechanism of action studies of genetic or pharmacologic screening hits.
  • Effectively working with research technicians and cross-functional project teams
  • Maintaining accurate records, writing reports, and preparing/giving presentations.

Qualifications

  • MD, PhD or MD/PhD in biological sciences or equivalent
  • Strong work ethic, positive attitude, team-centered mentality and most importantly a passion for developing new therapeutic approaches for cancer.
  • Background in molecular and/or cell biology, biochemistry, genomics or cancer biology.
  • Experience with genomics, functional genetic screens or mouse models of cancer (xenografts, PDXs, GEMMs) may be helpful but not mandatory.
  • Computational skills including computer programming are of interest but not mandatory
  • Excellent oral and written communication skills.
  • The ability to perform both self-directed and guided research is required. 
  • Must demonstrate outstanding ability to work effectively as part of an interdisciplinary team of scientists. 
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