A postdoctoral position in molecular metabolism is available in the laboratory of Nika Danial, PhD. The Danial lab investigates the metabolic mechanisms that regulate cellular and organismal adaptation to physiologic and pathologic stress conditions. Within this context, we study fundamental aspects of metabolic biology, including causes and consequences of cellular fuel utilization patterns and how processing of carbon substrates translates into specific metabolic signals that shape cell fate and function. To this end, we apply multi-disciplinary approaches that draw on biochemistry, mitochondrial physiology, chemical biology, proteomics and metabolomics. This research program has led to advancements in understanding anabolic and catabolic mechanisms that link altered cellular fuel usage to diseases such as cancer, diabetes and seizure disorders.
Several projects are currently available, including investigation of 1) metabolic crosstalks between inflammatory immune cells and target tissues; 2) cell autonomous and non-autonomous mechanisms underlying fuel utilization patterns and their control of tumor growth; 3) transcriptional control of lipid homeostasis by glucose/carbohydrates; and 4) glucose versus ketone body fuel decisions and the control of neuronal fate and function.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities include but are not limited to: design and rigorous execution of highly specialized and advanced molecular, cellular and biochemical techniques, to analyze and communicate experimental results, and to continuously stay up-to-date with scientific literature. All available research projects listed above include opportunities to conceptualize and develop novel hypotheses to be tested in a variety of in vitro and in vivo models. The successful postdoctoral candidate will be able to work both independently and as a member of a multi-disciplinary team, applying a variety of approaches such as proteomics, metabolomics, enzyme chemistry, mitochondrial physiology, cell signaling, chemical biology, functional genomics and computational biology.
Candidates must hold a Ph.D. and must have excellent track record of scientific research with peer-reviewed scientific publications. This position requires extensive cell and molecular biology experience. Candidates with background in protein chemistry, metabolic biochemistry and/or mass spectrometry-based metabolomics and experience with mouse models are especially preferred and will be prioritized.
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.