Research Fellow - Marasco Lab

Job Details

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Job ID:
27231

Location:
450 Brookline Ave, Boston, MA 02215

Category:
Research Laboratory

Employment Type:
Full time

Work Location:
Onsite:Up to 1 day remote/wk

Overview

Exciting opportunity for an exceptional post-doc applicant to conduct research on the effects of aging on influenza vaccine responsiveness in an effort to develop durable “Universal Influenza Vaccines”. Dr. Marasco is the Lead PI of this collaborative Harvard Medical School program that will examine T cell, B cell and metabolic aspects of aging (https://marascolab.dana-farber.org/). The project will involve both conceptual and technical innovations with the collaborating labs located within short walking distance from each other. Dr. Marasco’s lab will assess metabolic and population-based changes in B cell populations of young and aged individuals post influenza vaccination, with the aim of testing the paradigm that multiple subsets of antigen-specific B cells are altered in older individuals. Conceptional innovation will be pursued by investigating both germinal center and memory origins of antigen-specific B cells, antigen-specific molecular profiling to explore the effect of immune imprinting to the critical Hemagglutinin (HA) stem epitope(s), and performing simultaneous analysis of all B cell subsets and their binding specificities to different HA epitopes. Technical innovation for this project involves functional studies with the integration of LIBRA-Seq to identify B cell subsets directed to distinct epitopes on the HA head and stem domain. 

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

The funding available is for an initial appointment over three years and the starting date is flexible. The candidate will be expected to carry out bench research (both independently and as part of a team), participate in group discussions, and write research proposals and manuscripts.

Qualifications

Those with a strong background in immunology, B cell biology, structural biology, infectious diseases and bench experience in flow cytometry and molecular biology are encouraged to apply. Background knowledge in genomics and a good knowledge of R, python and/or other programming languages is desirable, but not required. Successful candidates should demonstrate a track record of research achievements and have excellent communication skills.

Please apply with a cover letter outlining research interests and a CV.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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