Research Tech - Senior

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Job ID:

450 Brookline Ave, Boston, MA 02215

Research Laboratory

Employment Type:
Full time

Work Location:
Onsite:Up to 1 day remote/wk


The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute and the Broad Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia.

A full-time Senior research technician position is available in the laboratory of Zuzana Tothova, MD, Ph.D. at Dana-Farber Cancer Institute.

We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a significant impact in healthcare and have the fortitude to work hard, you will succeed within this team.

This is an ideal mid-level entry position into the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed.

Previous team members have gone on to successful academic and career opportunities; graduate/medical school, independent faculty, consulting, and industry.

The successful candidate will be involved in a series of research activities, including building in vitro and in vivo human disease relevant models, experimental design, testing model systems in cellular and molecular assays, including in a high-throughput manner, use of next generation sequencing as well as molecular and

cellular biology experiments with a special emphasis on understanding the biology of human myeloid malignancies.

The candidate is expected to work largely independently on a daily basis after training, and will be closely mentored by the principal investigator. She/he will interact and collaborate closely with other scientists, biologists, chemists and computational biologists in the group and will have an opportunity to lead a group of more junior research technicians over time.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


· Oversees the maintenance of mouse colony, tissue processing including peripheral blood collection and organ dissection, sample processing and preparation for analysis.

· Performs mouse transplantation experiments, including tail vein, retroorbital and intrafemoral injections

· Performs basic molecular, biochemical and cellular biology experiments to investigate mechanisms that drive hematopoietic stem and progenitor cell transformation to myeloid malignancies

· Performs drug treatment experiments using cell lines, primary cell and mouse models of human disease

· Designs and carries out small independent projects and joins in team efforts for larger scale experiments.

· Documents, compiles, and analyzes experimental data. Reports data in oral and written reports.

· Attends team meetings to shares results, plan projects and experiments.

· Maintains and improves technical knowledge base.

· Operates and maintains laboratory equipment to complete investigations.

· Prepares, orders, and maintains stocks of necessary reagents, solutions and supplies.

· Other related tasks as required.


At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

· Bachelor degree in the life sciences or related field required.

· At least two years of experience after college in a molecular biology laboratory setting required.

· Experience with mouse work, basic laboratory techniques and principles of molecular biology required.

· Excellent written, documentation and oral communication skills required.

· Strong organizational skills, including the ability to handle a variety of tasks in a fast-paced environment required.

· A minimum of 2 years of lab research experience required.

· Passion for science and strong motivation

· Strong interpersonal, communication and organizational skills, including the ability to handle a variety of tasks in a fast-paced environment, positive attitude and attention to detail, as well as ability to think on one’s feet are required.

· Must possess a high level of initiative, curiosity and dedication, proactivity in identifying problems and solutions to address them.

· Must be a strong team player.

· Extensive mouse experience is a plus.

· Basic computational experience is not required but is a plus.

We are looking for candidates with at least 2 years of availability.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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