The laboratory of Dr. Pietro Genovese at the Dana-Farber Cancer Institute is seeking an energetic, efficient, and resourceful candidate with a strong propensity to team work who will participate in laboratory research and provide critical support to the principal investigator (PI) and his team.
The Genovese lab is a translational gene therapy research group that exploit a variety of cutting-edge gene editing technologies (CRISPR/Cas, TALEN, ZFN, base editors, epigenetic transcriptional regulators) to develop new therapeutic strategies for inherited and onco-hematologic diseases. They couple advanced molecular and cell biology approaches, such as viral vectors design, chimeric antigen receptors (CAR), next generation sequencing and ex vivo manipulation of stem cells and primary lymphocytes, with suitable preclinical models of disease to test novel therapeutics based on precision medicine both in vitro and in vivo. The successful candidate will be a team player capable of handling multiple tasks and adaptable to a fast-paced research environment. He/she will assist scientists in performing scientific research, development and/or clinical tasks of varying complexity. In addition, this position will assist in the set-up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results.
The Dana-Farber Cancer Institute (DFCI), located in Boston and the surrounding communities, brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Genovese lab (genoveselab.dana-farber.org) is part of the Dana-Farber/Boston Children’s Gene Therapy Program, one the most extensive and long-running pediatric gene therapy program in the world, featuring a multidisciplinary team that includes physicians, nurses, researchers, clinical research coordinators, and program administrators. Because our team addresses the full spectrum of gene therapy from basic research to clinical treatment, our program is continually at the forefront of gene therapy care. Since 2010, we have treated 36 patients from 11 countries through eight gene therapy clinical trials.
The successful candidate will work on projects aimed at developing innovative gene therapy protocols for the treatment of inherited and acquired immune-disorders, such as primary immunodeficiencies and leukemias. He/she will be required to contribute to research by leading in the management of the lab and support investigators in molecular and cellular biology, viral vector production, maintenance of cell cultures and mouse colony and assisting with experiments in rodents including human stem cells xeno-transplantations.
Specific responsibilities include:
Specific skills and personal attributes required include: high energy multi-tasker, supremely organized with exquisite attention to detail, exemplary communication skills, computer and technology savvy, strong expertise with molecular biology techniques, proficiency in plasmid cloning and cellular biology; experience in mice handling and next generation sequencing would be also appreciated. Bachelor's degree required with a major in biology or chemistry preferred. Previous lab research experience is required (undergraduate experience will be considered) and knowledge of information and techniques related to either biology, chemistry, or medicine is preferred.
Dana-Farber Cancer Institute offers competitive compensation (based on qualification, experience and responsibilities adopted) and unmatched benefits. Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.