Job ID:

450 Brookline Ave, Boston, MA 02215

Research Laboratory

Employment Type:
Full time

Work Location:
Onsite: 4-5 days onsite/week


Cancer Biology Department, Xin Zhou Lab

Dr. Xin Zhou of the Dana-Farber Cancer Institute and Harvard Medical School seeks a highly motivated research technician for her research group to work on our newest ideas and to help maintain the lab ( This is an excellent opportunity for recent bachelor's or master’s graduates who are seeking immersive research experience prior to continuing their career at a graduate or medical school, or for individuals committed to a long-term research technician position.

In the Zhou lab, our priority is to maintain the highest level of rigor in science and to foster a nurturing and inclusive environment. We are a group of scientists who are passionate about bioengineering, therapeutic antibodies, and cell signaling, and we are committed to mentoring a new generation of scientists!

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world-renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


  • Working at the interface of biomolecular engineering and disease biology, the Zhou Lab is breaking new ground with innovative biotechnologies and biomedicine designs for complex diseases that have been traditionally challenging to address. Our research projects encompass the development of innovative protein degraders targeting challenging human diseases such as non-small cell lung cancer, signaling reprogramming of chimeric antigen receptor T cells, and biosensing of disease environments to inform the design of advanced pro-drugs and pro-antibodies.

    We are deeply interested in engineering versatile functional proteins that can distinguish and respond to various signals within a disease context, modulate cancer and immune cell signaling, and develop novel methods for mammalian cell manipulation. We integrate methods from chemical biology, synthetic biology, and protein design to develop the next generation of molecular biotechnologies, diagnostics, and therapeutics.

    The recruited member will work closely with Dr. Xin Zhou and senior lab personnel to design and implement protein and cellular engineering experiments. The recruited member can learn diverse laboratory techniques:

    • Molecular cloning, cell culture, protein expression, cellular assays
    • Biophysical characterization: binding measurement, structural analysis
    • Protein evolution: Phage display, yeast display, protein library construction
    • Immune cell (CAR-T, NK, etc.) engineering and characterization
    • Fluorescence microscopy
    • Cell-based phenotypic screen

    As they build skills, the successful applicant will be expected to work with greater independence to execute SOPs across multiple projects; significant contributions of data and analysis will be recognized with co-authorship on scientific manuscripts.

    The Zhou Lab has state-of-the-art facilities and a highly collaborative, interdisciplinary environment in Dana-Farber’s Longwood Center. We are part of the Chemical Biology program at the Dana-Farber and the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. We collaborate with disease-focused scientists and biotherapeutics scientists in both industry and academia to pursue new therapeutic approaches addressing human disease conditions.


  • Minimum qualifications include a bachelor's-level degree in biology, chemistry, bioengineering, or a related field, hands-on experience in laboratory research, and basic computer skills. Demonstrated experience in molecular biology or protein expression is required. The successful candidate for this position will be energetic, eager to learn new techniques, and excited by the opportunity to work in a supportive and collegial multidisciplinary lab environment. Additional requirements for this position include strong interpersonal and organizational skills, attention to detail, methodical record-keeping, and a desire to contribute to research projects both independently and within a team. At least two years of commitment to this position are expected. The start date of this position is flexible and can be as early as Spring, 2023. Candidates are invited to send Dr. Xin Zhou a CV, a cover letter, and contact information for three references.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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