Scientist II - Antibody Discovery/Assay Development

Job Details

Job ID:

450 Brookline Ave, Boston, MA 02215

Research Laboratory

Employment Type:
Full time

Work Location:
Onsite: 100% onsite


We have developed an innovative new platform for the rapid, high throughput discovery of immune-oncology targets and therapeutic antibodies to combat ovarian cancer. We are seeking a scientist to drive antibody/target discovery and assay development efforts within our growing team. As an integral part of our team, the scientist will lead efforts for the development of cell-based binding and functional assays, antibody screening, novel surface target validation, and antibody characterization. This is a unique opportunity to creatively contribute to many in vitro and in vivo aspects of therapeutic antibody discovery. The successful candidate will have a leading role within a team of scientists and research associates. Individuals with an entrepreneurial spirit that are interested to transition into industry are particularly encouraged to apply.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


  • Oversee and perform antibody screening and characterization
  • Lead assay development for binding and functional antibody characterization
  • Lead efforts to explore various antibody modalities including ADCs, and T-cell engagers
  • Contribute to the development/establishment of in vitro and in vivo cancer models
  • Manage relationships with contract research organizations
  • Help with the identification of lead candidates by literature evaluation and expression analysis
  • Help with the design and implementation of in vivo studies
  • Work as part of the scientific team to implement experimental plans and help were needed
  • Mentor junior team members



  • PhD in Molecular and Cellular Biology or related field with 2+ years post-graduate experience
  • Hands-on experience with mammalian cell culture models and cell line engineering
  • Significant experience in antibody discovery and/or antibody engineering as well as design, execution, and analysis of assays for lead identification
  • Significant experience with biochemical antibody characterization (Octet, Biacore)
  • Proficiency in basic molecular biology and biochemistry techniques
  • Collaborative, team-oriented work ethic

Desired additional skills (preferred, not required):

  • Experience with phage display
  • Knowledge of in vivo preclinical oncology models
  • Experience managing CROs
  • Experience managing junior team members

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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