Senior Research Technician - Lindsley Lab

Job Details

Job ID:

450 Brookline Ave, Boston, MA 02215

Research Laboratory

Employment Type:
Full time

Work Location:
Onsite: 100% onsite


A Senior Research Technician position is available in a laboratory of R. Coleman Lindsley, MD, PhD at the Dana-Farber Cancer Institute (DFCI) and Harvard Medical School in Boston, Massachusetts ( We use interdisciplinary approaches at the interface of genomics and molecular biology to understand the mechanisms of human cancer, with the aim of translating these insights into novel therapies for patients. Our specific focus is on blood cancers, such as acute leukemia and myelodysplastic syndromes, in adults and children.  Technical skills involving tissue culture, flow cytometry, and standard molecular and cell biology techniques are highly desirable. Prior experience with small animal models would be an advantage but is not required.

We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.


  • The Senior Research Technician will work under supervision to support the Lindsley Laboratory in a variety of ways:
    • Perform in vivo (mouse) experiments, including blood and tissue collections, treatments and injections, and organ harvest.
    • Assist with maintenance and monitoring of the animal colony, breeding, weaning, tagging, and genotyping.
    • Maintain cells in culture and perform in vitro experiments at biological safety levels 1 and 2.
    • Perform standard molecular biology and biochemical techniques, such as western blots, DNA/RNA isolations, PCR/qPCR, and flow cytometry 
    • Conduct standardized biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances, such as blood, drugs, and animals.
    • Analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to lab members.
    • Maintain detailed notebook of all work-related activities.
    • Monitor laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.
    • Collaborate with laboratory manager and staff scientists for the development, modification and improvement of standard operating procedures.
    • Assist with the daily upkeep of the lab, overseeing the completion of routine lab tasks, deliveries of supplies, and maintenance of lab stocks. 
    • Use computers, equipment, and high-technology applications to perform work duties.
  • Senior Research Technician

    No supervisory responsibilities.  Normally receives general instructions on routine work, detailed instructions on new projects or assignments.


  • B.A/B.S with significant biological/physical science coursework preferred. Experience with techniques in molecular biology and cell biology is highly desirable.

  • Requires a minimum of 1-4 years related experience. 

  • Developing technical expertise, applies Institute policies and procedures to resolve a variety of issues. 

  • Works on problems of moderate scope where analysis of situations or data requires a review of a variety of factors. 

  • Exercises judgment within defined procedures and practices to determine appropriate action.  Builds productive internal/external working relationships.

Laboratory environment: occasionally works with toxic chemicals, biohazards, animals, and substances emitting unpleasant odors

The ideal addition to the Lindsley Laboratory will:

  • Be kind and collegial
  • Enjoy working in a team environment with a wide variety of faculty and staff
  • Have good oral and written communication skills
  • Be able to identify potential problems and trouble-shoot solutions
  • Possess outstanding planning, organizational, multi-tasking skills

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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